Rubella Virus Replication Complexes Are Virus-Modified Lysosomes
نویسندگان
چکیده
منابع مشابه
RNA Virus Replication Complexes
The majority of viruses infecting animals and plants today are RNA viruses [1]. There are double-stranded (ds) RNA viruses with dsRNA genomes, as well as (+) and (2)RNA viruses whose genomes are single-stranded (ss) RNA of either positive or negative polarity. RNA viruses have small genomes that rarely exceed 30 kb in size, and a large portion of their genomes is used to encode proteins involve...
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Rubella virus (RV) is the causative agent of the disease known more popularly as German measles. Rubella is predominantly a childhood disease and is endemic throughout the world. Natural infections of rubella occur only in humans and are generally mild. Complications of rubella infection, most commonly polyarthralgia in adult women, do exist; occasionally more serious sequelae occur. However, t...
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The distribution and morphology of mitochondria are dramatically affected during infection with rubella virus (RV). Expression of the capsid, in the absence of other viral proteins, was found to induce both perinuclear clustering of mitochondria and the formation of electron-dense intermitochondrial plaques, both hallmarks of RV-infected cells. We previously identified p32, a host cell mitochon...
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The paper deals with a review article of nervous system disorders caused by rubella virus (RV) infection. The diseases are categorized as acute and chronic, the former consists of acute encephalitis and peripheral neuropathy, and the latter congenital rubella syndrome and progressive rubella panencephalitis. Acute rubella encephalitis occurs one case per 6,000 rubella patients either at viremia...
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The rubella virus (RV)-encoded protein NSP90, which contains the retinoblastoma protein (Rb)-binding motif LXCXE, interacts with Rb and RV replication is reduced in cells lacking Rb. Whether the LXCXE motif of RV NSP90 itself is essential for Rb binding and virus replication is not known. Therefore, in the present study, the functional role of this motif was investigated by site-directed mutage...
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ژورنال
عنوان ژورنال: Virology
سال: 1998
ISSN: 0042-6822
DOI: 10.1006/viro.1997.8906